592 research outputs found
Wavelet probabilistic neural networks
In this article, a novel wavelet probabilistic neural network (WPNN), which is a generative-learning wavelet neural network that relies on the wavelet-based estimation of class probability densities, is proposed. In this new neural network approach, the number of basis functions employed is independent of the number of data inputs, and in that sense, it overcomes the well-known drawback of traditional probabilistic neural networks (PNNs). Since the parameters of the proposed network are updated at a low and constant computational cost, it is particularly aimed at data stream classification and anomaly detection in off-line settings and online environments where the length of data is assumed to be unconstrained. Both synthetic and real-world datasets are used to assess the proposed WPNN. Significant performance enhancements are attained compared to state-of-the-art algorithms
The first CO+ image: Probing the HI/H2 layer around the ultracompact HII region Mon R2
The CO+ reactive ion is thought to be a tracer of the boundary between a HII
region and the hot molecular gas. In this study, we present the spatial
distribution of the CO+ rotational emission toward the Mon R2 star-forming
region. The CO+ emission presents a clumpy ring-like morphology, arising from a
narrow dense layer around the HII region. We compare the CO+ distribution with
other species present in photon-dominated regions (PDR), such as [CII] 158 mm,
H2 S(3) rotational line at 9.3 mm, polycyclic aromatic hydrocarbons (PAHs) and
HCO+. We find that the CO+ emission is spatially coincident with the PAHs and
[CII] emission. This confirms that the CO+ emission arises from a narrow dense
layer of the HI/H2 interface. We have determined the CO+ fractional abundance,
relative to C+ toward three positions. The abundances range from 0.1 to
1.9x10^(-10) and are in good agreement with previous chemical model, which
predicts that the production of CO+ in PDRs only occurs in dense regions with
high UV fields. The CO+ linewidth is larger than those found in molecular gas
tracers, and their central velocity are blue-shifted with respect to the
molecular gas velocity. We interpret this as a hint that the CO+ is probing
photo-evaporating clump surfaces.Comment: The main text has 4 pages, 2 pages of Appendix, 4 figures, 1 table.
Accepted for publication in Astronomy and Astrophysics letter
The Ring Imaging Cherenkov detector (RICH) of the AMS experiment
The Alpha Magnetic Spectrometer (AMS) experiment to be installed on the
International Space Station (ISS) will be equipped with a proximity focusing
Ring Imaging Cherenkov (RICH) detector for measuring the electric charge and
velocity of the charged cosmic particles. A RICH prototype consisting of 96
photomultiplier units, including a piece of the conical reflector, was built
and its performance evaluated with ion beam data. Preliminary results of the
in-beam tests performed with ion fragments resulting from collisions of a 158
GeV/c/nuc primary beam of Indium ions (CERN SPS) on a Pb target are reported.
The collected data included tests to the final front-end electronics and to
different aerogel radiators. Cherenkov rings for a large range of charged
nuclei and with reflected photons were observed. The data analysis confirms the
design goals. Charge separation up to Fe and velocity resolution of the order
of 0.1% for singly charged particles are obtained.Comment: 29th International Conference on Cosmic Rays (Pune, India
The AMS-RICH velocity and charge reconstruction
The AMS detector, to be installed on the International Space Station,
includes a Ring Imaging Cerenkov detector with two different radiators, silica
aerogel (n=1.05) and sodium fluoride (n=1.334). This detector is designed to
provide very precise measurements of velocity and electric charge in a wide
range of cosmic nuclei energies and atomic numbers. The detector geometry, in
particular the presence of a reflector for acceptance purposes, leads to
complex Cerenkov patterns detected in a pixelized photomultiplier matrix. The
results of different reconstruction methods applied to test beam data as well
as to simulated samples are presented. To ensure nominal performances
throughout the flight, several detector parameters have to be carefully
monitored. The algorithms developed to fulfill these requirements are
presented. The velocity and charge measurements provided by the RICH detector
endow the AMS spectrometer with precise particle identification capabilities in
a wide energy range. The expected performances on light isotope separation are
discussed.Comment: Contribution to the ICRC07, Merida, Mexico (2007); Presenter: F.
Bara
The RICH detector of the AMS-02 experiment: status and physics prospects
The Alpha Magnetic Spectrometer (AMS), whose final version AMS-02 is to be
installed on the International Space Station (ISS) for at least 3 years, is a
detector designed to measure charged cosmic ray spectra with energies up to the
TeV region and with high energy photon detection capability up to a few hundred
GeV. It is equipped with several subsystems, one of which is a proximity
focusing RICH detector with a dual radiator (aerogel+NaF) that provides
reliable measurements for particle velocity and charge. The assembly and
testing of the AMS RICH is currently being finished and the full AMS detector
is expected to be ready by the end of 2008. The RICH detector of AMS-02 is
presented. Physics prospects are briefly discussed.Comment: 5 pages. Contribution to the 10th ICATPP Conference on Astroparticle,
Particle, Space Physics, Detectors and Medical Physics Applications (Como
2007). Presenter: Rui Pereir
HTLV-1 infection in solid organ transplant donors and recipients in Spain
Background: HTLV-1 infection is a neglected disease, despite infecting 10–15 million people worldwide and
severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1
associated illnesses due to immunosuppression, screening is being widely considered in the transplantation
setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ
transplants in a survey conducted in Spain.
Methods: All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV
antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients
attended since the year 2008.
Results: A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312
(42.2%), of whom 17 (0.3%) were living kidney donors. The remaining 3439 (59.8%) were recipients. Spaniards
represented nearly 80%.
Overall, 9 individuals (0.16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients.
Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from
Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed
within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be
removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in
dialysis but otherwise asymptomatic.
Conclusion: The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in
Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ
transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along
with the rapid development of subacute myelopath
Gas phase Elemental abundances in Molecular cloudS (GEMS) : II. On the quest for the sulphur reservoir in molecular clouds: the H2S case
Context. Sulphur is one of the most abundant elements in the Universe. Surprisingly, sulphuretted molecules are not as abundant as expected in the interstellar medium and the identity of the main sulphur reservoir is still an open question.Aims. Our goal is to investigate the H2S chemistry in dark clouds, as this stable molecule is a potential sulphur reservoir.Methods. Using millimeter observations of CS, SO, H2S, and their isotopologues, we determine the physical conditions and H2S abundances along the cores TMC 1-C, TMC 1-CP, and Barnard 1b. The gas-grain model NAUTILUS is used to model the sulphur chemistry and explore the impact of photo-desorption and chemical desorption on the H2S abundance.Results. Our modeling shows that chemical desorption is the main source of gas-phase H2S in dark cores. The measured H2S abundance can only be fitted if we assume that the chemical desorption rate decreases by more than a factor of 10 when n(H) > 2 x 10(4). This change in the desorption rate is consistent with the formation of thick H2O and CO ice mantles on grain surfaces. The observed SO and H2S abundances are in good agreement with our predictions adopting an undepleted value of the sulphur abundance. However, the CS abundance is overestimated by a factor of 5-10. Along the three cores, atomic S is predicted to be the main sulphur reservoir.Conclusions. The gaseous H2S abundance is well reproduced, assuming undepleted sulphur abundance and chemical desorption as the main source of H2S. The behavior of the observed H2S abundance suggests a changing desorption efficiency, which would probe the snowline in these cold cores. Our model, however, highly overestimates the observed gas-phase CS abundance. Given the uncertainty in the sulphur chemistry, we can only conclude that our data are consistent with a cosmic elemental S abundance with an uncertainty of a factor of 10.Peer reviewe
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia
Acute lymphoblastic leukemia (ALL) is a malignant disease of the white blood cells. The etiology of ALL is believed to be multifactorial and likely to involve an interplay of environmental and genetic variables. We performed a genome-wide association study of 355 750 single-nucleotide polymorphisms (SNPs) in 474 controls and 419 childhood ALL cases characterized by a t(12;21)(p13;q22) — the most common chromosomal translocation observed in childhood ALL — which leads to an ETV6–RUNX1 gene fusion. The eight most strongly associated SNPs were followed-up in 951 ETV6-RUNX1-positive cases and 3061 controls from Germany/Austria and Italy, respectively. We identified a novel, genome-wide significant risk locus at 3q28 (TP63, rs17505102, PCMH=8.94 × 10−9, OR=0.65). The separate analysis of the combined German/Austrian sample only, revealed additional genome-wide significant associations at 11q11 (OR8U8, rs1945213, P=9.14 × 10−11, OR=0.69) and 8p21.3 (near INTS10, rs920590, P=6.12 × 10−9, OR=1.36). These associations and another association at 11p11.2 (PTPRJ, rs3942852, P=4.95 × 10−7, OR=0.72) remained significant in the German/Austrian replication panel after correction for multiple testing. Our findings demonstrate that germline genetic variation can specifically contribute to the risk of ETV6–RUNX1-positive childhood ALL. The identification of TP63 and PTPRJ as susceptibility genes emphasize the role of the TP53 gene family and the importance of proteins regulating cellular processes in connection with tumorigenesis
Rapid subacute myelopathy following kidney transplantation from HTLV-1 donors: role of immunosuppresors and failure of antiretrovirals
Two kidney transplant recipients from a single donor became infected with HTLV-1 (human T-lymphotropic virus type 1) in Spain. One developed myelopathy 8 months following surgery despite early prescription of antiretroviral therapy. The allograft was removed from the second recipient at month 8 due to rejection and immunosuppressors discontinued. To date, 3 years later, this patient remains infected but asymptomatic. HTLV-1 infection was recognized retrospectively in the donor, a native Spaniard who had sex partners from endemic regions. Our findings call for a reappraisal of screening policies on donor-recipient organ transplantation. Based on the high risk of disease development and the large flux of persons from HTLV-1 endemic regions, pre-transplant HTLV-1 testing should be mandatory in Spain
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